Filed from 3 published puzzles

ABSOLUTELY

Set to 2 different clues across 3 published puzzles, most often "Yes!" — The New York Times, Monday, 4 January 1999.

10 letters

Every clue on record, most used first

"Yes!"2 times
The New York Times — Monday, 4 January 1999
"No doubt!"once
The New York Times — Wednesday, 11 March 2009

Other answers to these clues

ASSENT6 letters
AYE3 letters
BUTOFCOURSE11 letters
BYALLMEANS10 letters
IDO3 letters
IKIDYOUNOT10 letters
ITISSO6 letters
MAAM4 letters
ORNO4 letters
SIR3 letters
SIRREE6 letters
SURETHING9 letters