ACAN

Set to 3 different clues across 8 published puzzles, most often “Open ___ of worms” — The New York Times, Wednesday, 27 April 2011.

4 letters

Every clue on record, most used first

Open ___ of worms6 times
The New York Times — Wednesday, 27 April 2011
Open up ___ of wormsonce
The New York Times — Monday, 14 December 2009
"Do you have Prince Albert in ___?"once
The New York Times — Sunday, 2 November 2003