Filed from 13 published puzzles

ARTLESS

Set to 7 different clues across 13 published puzzles, most often “Unaffected” — The New York Times, Sunday, 1 May 2005.

7 letters

Every clue on record, most used first

Unaffected4 times
The New York Times — Sunday, 1 May 2005
Natural3 times
The New York Times — Friday, 11 July 2008
Naive2 times
The New York Times — Friday, 13 August 2004
Ingenuous ... or like 17-, 24-, 50- and 60-Acrossonce
The New York Times — Thursday, 14 June 2007
Lacking guileonce
The New York Times — Monday, 7 August 2006
Ingenuousonce
The New York Times — Thursday, 2 August 2001
Unskillfulonce
The New York Times — Thursday, 16 November 1995

Other answers to these clues

ACT3 letters
AFRO4 letters
BORN4 letters
INBORN6 letters
INNATE6 letters
LIFELIKE8 letters
NAIVE5 letters
REAL4 letters
UNDYED6 letters
UNSTAGY7 letters
WILD4 letters