BLOW

Set to 20 different clues across 21 published puzzles, most often “Squander” — The New York Times, Tuesday, 30 December 2008.

4 letters

Every clue on record, most used first

Squander2 times
The New York Times — Tuesday, 30 December 2008
Explodeonce
The New York Times — Wednesday, 4 May 2011
Big windonce
The New York Times — Sunday, 4 April 2010
Completely bungleonce
The New York Times — Sunday, 23 March 2008
Whammyonce
The New York Times — Friday, 19 January 2007
Explode, as a volcanoonce
The New York Times — Monday, 3 March 2003
Severe setbackonce
The New York Times — Thursday, 25 July 2002
Ruin big-timeonce
The New York Times — Saturday, 9 March 2002
Totally botchonce
The New York Times — Wednesday, 11 April 2001
Big stormonce
The New York Times — Wednesday, 10 May 2000
With 43-Across, use bubble gum?once
The New York Times — Thursday, 11 February 1999
Throw awayonce
The New York Times — Sunday, 19 April 1998