BORGIA

Set to 3 different clues across 3 published puzzles, most often “Enemy of a Medici” — The New York Times, Sunday, 31 July 2011.

6 letters

Every clue on record, most used first

Enemy of a Medicionce
The New York Times — Sunday, 31 July 2011
Model for Machiavelli's "The Prince"once
The New York Times — Saturday, 20 February 2010
Infamous Italian family nameonce
The New York Times — Monday, 1 February 1999