BUTENE

Set to 2 different clues across 4 published puzzles, most often “C4H8” — The New York Times, Friday, 30 July 2010.

6 letters

Every clue on record, most used first

C4H83 times
The New York Times — Friday, 30 July 2010
Hydrocarbon derived from petroleumonce
The New York Times — Sunday, 25 January 1998