CODEINE
Set to 2 different clues across 2 published puzzles, most often “Opium product” — The New York Times, Friday, 3 October 2008.
7 letters
Every clue on record, most used first
- Opium productonce
The New York Times — Friday, 3 October 2008
- Opium compoundonce
The New York Times — Sunday, 28 February 1999