Filed from 6 published puzzles

DESPITE

Set to 3 different clues across 6 published puzzles, most often “Notwithstanding” — The New York Times, Thursday, 17 April 2003.

7 letters

Every clue on record, most used first

Notwithstanding3 times
The New York Times — Thursday, 17 April 2003
Regardless of2 times
The New York Times — Monday, 31 August 2009
In the face ofonce
The New York Times — Saturday, 6 March 1999

Other answers to these clues

ALBEIT6 letters
INSPITEOF9 letters