Filed from 3 published puzzles

DETONATE

Set to 3 different clues across 3 published puzzles, most often “Set off, in a big way” — The New York Times, Thursday, 4 June 2009.

8 letters

Every clue on record, most used first

Set off, in a big wayonce
The New York Times — Thursday, 4 June 2009
Set offonce
The New York Times — Friday, 7 March 2008
Go offonce
The New York Times — Saturday, 29 June 1996

Other answers to these clues

APART5 letters
DETONATED9 letters
ERR3 letters
ERUPT5 letters
IGNITE6 letters
INITIATE8 letters
IRK3 letters
MOVEAWAY8 letters
POP3 letters
STARTED7 letters
TRIGGER7 letters
WANDER6 letters