DOPA
Set to 3 different clues across 3 published puzzles, most often “L-___ (Parkinson's treatment)” — The New York Times, Tuesday, 7 September 2010.
4 letters
Every clue on record, most used first
- L-___ (Parkinson's treatment)once
The New York Times — Tuesday, 7 September 2010
- L-___ (treatment for parkinsonism)once
The New York Times — Wednesday, 18 April 2007
- Neurotransmitter amino acidonce
The New York Times — Saturday, 18 October 1997