DOTCOM

Set to 3 different clues across 4 published puzzles, most often “E-business” — The New York Times, Monday, 19 September 2005.

6 letters

Every clue on record, most used first

E-business2 times
The New York Times — Monday, 19 September 2005
Techie's companyonce
The New York Times — Monday, 15 February 2010
Business that may have gone boom and then bust in the '90sonce
The New York Times — Monday, 31 March 2008