FIRSTBORN

Set to 2 different clues across 4 published puzzles, most often “Heir to a throne, typically” — The New York Times, Tuesday, 27 January 2009.

9 letters

Every clue on record, most used first

Heir to a throne, typically2 times
The New York Times — Tuesday, 27 January 2009
Like Cain2 times
The New York Times — Sunday, 7 October 2007