Filed from 4 published puzzles

GNAWAT

Set to 4 different clues across 4 published puzzles, most often “Really bother” — The New York Times, Thursday, 8 July 2010.

6 letters

Every clue on record, most used first

Really botheronce
The New York Times — Thursday, 8 July 2010
Bother horriblyonce
The New York Times — Monday, 20 March 2006
Bother incessantlyonce
The New York Times — Thursday, 29 August 2002
Gradually corrodeonce
The New York Times — Saturday, 15 December 2001

Other answers to these clues

ANNOY5 letters
EATAT5 letters
MOLEST6 letters