HEA

Set to 4 different clues across 7 published puzzles, most often "Isn't ___ bit like you and me?" (Beatles lyric) — The New York Times, Thursday, 25 September 2008.

3 letters

Every clue on record, most used first

"Isn't ___ bit like you and me?" (Beatles lyric)4 times
The New York Times — Thursday, 25 September 2008
"? made ___ woman": Genesisonce
The New York Times — Sunday, 11 February 2007
"Hath ___ sister?": Shak.once
The New York Times — Friday, 6 December 2002
With 46-Across, bereft, literallyonce
The New York Times — Thursday, 11 April 2002