Filed from 3 published puzzles

HEADACHE

Set to 3 different clues across 3 published puzzles, most often “Ibuprofen target” — The New York Times, Wednesday, 2 June 2010.

8 letters

Every clue on record, most used first

  • Ibuprofen targetonce

    The New York Times — Wednesday, 2 June 2010

  • Problemonce

    The New York Times — Sunday, 11 January 2004

  • Major annoyanceonce

    The New York Times — Thursday, 18 December 2003

Other answers to these clues