Filed from 37 published puzzles

IRKS

Set to 18 different clues across 37 published puzzles, most often “Bugs” — The New York Times, Thursday, 11 June 2009.

4 letters

Every clue on record, most used first

  • Bugs6 times

    The New York Times — Thursday, 11 June 2009

  • Rubs the wrong way5 times

    The New York Times — Sunday, 19 April 2009

  • Nettles3 times

    The New York Times — Sunday, 27 March 2011

  • Ticks off3 times

    The New York Times — Tuesday, 2 November 1999

  • Peeves2 times

    The New York Times — Monday, 16 May 2011

  • Grates on2 times

    The New York Times — Wednesday, 1 July 2009

  • Miffs2 times

    The New York Times — Sunday, 6 July 2008

  • Vexes2 times

    The New York Times — Tuesday, 27 March 2007

  • Bothers2 times

    The New York Times — Monday, 1 March 2004

  • Exasperates2 times

    The New York Times — Saturday, 8 February 2003

  • Gets toonce

    The New York Times — Thursday, 18 December 2008

  • Annoysonce

    The New York Times — Monday, 11 June 2007

Other answers to these clues