MISSIS
Set to 2 different clues across 2 published puzzles, most often “Wife, colloquially” — The New York Times, Sunday, 29 July 2007.
6 letters
Every clue on record, most used first
- Wife, colloquiallyonce
The New York Times — Sunday, 29 July 2007
- "Little woman"once
The New York Times — Thursday, 15 January 1998