ORYX

Set to 7 different clues across 12 published puzzles, most often “African antelope” — The New York Times, Sunday, 10 September 2006.

4 letters

Every clue on record, most used first

African antelope4 times
The New York Times — Sunday, 10 September 2006
Endangered antelope3 times
The New York Times — Thursday, 16 March 2006
Serengeti antelopeonce
The New York Times — Sunday, 17 July 2011
Large African antelopeonce
The New York Times — Wednesday, 18 August 2010
Animal some believe to be the source of the unicorn mythonce
The New York Times — Friday, 30 May 2008
Straight-horned African animalonce
The New York Times — Tuesday, 2 October 2007
African grazeronce
The New York Times — Friday, 30 September 2005