YUP
Set to 6 different clues across 8 published puzzles, most often “Nope's counterpart” — The New York Times, Monday, 21 August 2006.
3 letters
Every clue on record, most used first
- Nope's counterpart2 times
The New York Times — Monday, 21 August 2006
- "Uh-huh"2 times
The New York Times — Sunday, 5 February 2006
- "You betcha"once
The New York Times — Sunday, 3 June 2001
- Informal affirmativeonce
The New York Times — Sunday, 18 March 2001
- Western agreement?once
The New York Times — Sunday, 15 August 1999
- Oater affirmativeonce
The New York Times — Sunday, 20 July 1997