ANGUISH
Set to 4 different clues across 4 published puzzles, most often “It's heartrending” — The New York Times, Thursday, 21 September 2006.
7 letters
Every clue on record, most used first
- It's heartrendingonce
The New York Times — Thursday, 21 September 2006
- Worryonce
The New York Times — Thursday, 6 October 2005
- Tortureonce
The New York Times — Friday, 24 July 1998
- Distressonce
The New York Times — Sunday, 26 March 1995