Filed from 22 published puzzles

UNEASE

Set to 16 different clues across 22 published puzzles, most often “Nervousness” — The New York Times, Sunday, 25 April 2010.

6 letters

Every clue on record, most used first

  • Nervousness4 times

    The New York Times — Sunday, 25 April 2010

  • Disquiet3 times

    The New York Times — Wednesday, 28 June 2000

  • Discomfort2 times

    The New York Times — Tuesday, 20 February 2007

  • Butterflies, sayonce

    The New York Times — Saturday, 29 August 2009

  • Distressonce

    The New York Times — Friday, 22 May 2009

  • Fidgetinessonce

    The New York Times — Saturday, 13 September 2008

  • Heebie-jeebiesonce

    The New York Times — Tuesday, 20 May 2008

  • Fidgety feelingonce

    The New York Times — Tuesday, 24 April 2007

  • The heebie-jeebiesonce

    The New York Times — Wednesday, 6 December 2006

  • Edginessonce

    The New York Times — Saturday, 10 September 2005

  • Malaiseonce

    The New York Times — Friday, 13 May 2005

  • Anxietyonce

    The New York Times — Wednesday, 16 February 2005

Other answers to these clues